Geometric modeling and processing

Ambito disciplinare

  1. Articolo su rivista2022

    Handy: Novel hand exoskeleton for personalized rehabilitation

    Aruanno B., Covarrubias M.,

    Computer-Aided Design and Applications, 19(3), pp. 405-425

    Additive manufacturingMethods for medical applicationsProduct design and engineeringVirtual and augmented reality

    Abstract

    Worldwide, stroke is the third cause of disability. The majority of people affected by this disease cannot perform activities of daily living. Bringing the therapy to the patients' home is complex, and in literature, there are still open challenges to face. Starting from therapists' and patients' needs, this paper describes a possible solution: HANDY, a rehabilitative active hand exoskeleton for post-stroke patients. With a desktop application, they perform three different types of exercises: passive, active and based on activities of daily living. They can also control the exoskeleton themselves in a serious-game approach with a leap motion controller. We evaluated our method with patients at the Villa Beretta rehabilitative center. Preliminary results from the session about comfort, usability and willingness to utilize the system are promising.

    Keywords: Additive manufacturing , CAD modeling , Hand exoskeleton , Interactive applications , Stroke

  2. Articolo su rivista2022

    A Structured Approach for the Design and Manufacturing of Titanium Cranial Prostheses via Sheet Metal Forming

    Palumbo G., Ambrogio G., Crovace A., Piccininni A., Cusanno A., Guglielmi P., De Napoli L., Serratore G.,

    Metals, 12(2)

    3D scanningGeometric dimensioning, tolerancing and inspectionMethods for medical applicationsProduct design and engineering

    Abstract

    Currently, the growing need for highly customized implants has become one of the key aspects to increase the life expectancy and reduce time and costs for prolonged hospitalizations due to premature failures of implanted prostheses. According to the literature, several technological solutions are considered suitable to achieve the necessary geometrical complexity, from the conventional subtractive approaches to the more innovative additive solutions. In the case of cranial prostheses, which must guarantee a very good fitting of the region surrounding the implant in order to minimize micromotions and reduce infections, the need of a product characterized by high geometrical complexity combined with both strength and limited weight, has pushed the research towards the adoption of manufacturing processes able to improve the product's quality but being fast and flexible enough. The attention has been thus focused in this paper on sheet metal forming processes and, namely on the Single Point Incremental Forming (SPIF) and the Superplastic Forming (SPF). In particular, the complete procedure to design and produce titanium cranial prostheses for in vivo tests is described: starting from Digital Imaging and COmmunications in Medicine (DICOM) images of the ovine animal, the design was conducted and the production process simulated to evaluate the process parameters and the production set up. The forming characteristics of the prostheses were finally evaluated in terms of thickness distributions and part's geometry. The effectiveness of the proposed methodology has been finally assessed through the implantation of the manufactured prostheses in sheep.

    Keywords: Custom prosthesis , In vivo tests , Single point incremental forming , Superplastic forming , Ti‐6Al‐4V ELI

  3. Contributo a convegno2022

    A New Table to Manage 1D Tolerances Stack-Up

    Rizzuti S., De Napoli L.,

    Lecture Notes in Mechanical Engineering, pp. 861-871

    Engineering educationGeometric dimensioning, tolerancing and inspection

    Abstract

    Analyzing an assembly and recognizing how the components can mate with each other in order to satisfy the functionality for which they have been designed is not a trivial task. Teaching such a problem to engineering students requires they are familiar with a set of components and how much larger or thin can be the errors intrinsically related to the technologies employed in their production. A set of steps are necessary to reasoning about the right identification of a chain of dimensions that influences a functionality. Then can be useful to have a table where collect the data, especially when the number of parts is relevant. The paper presents a new format for the table that can be used in all kinds of problems that may occur in design: analysis, analysis with constraints, and synthesis. The way how to employ such a table and the steps to solve each problem is discussed with known examples.

    Keywords: Modeling , Tolerance analysis and synthesis , Tolerance stack-up

  4. Articolo su rivista2022

    Efficient partial elements computation for the non-orthogonal PEEC method including conductive, dielectrics and magnetic materials

    Romano D., Di Angelo L., Kovacevic-Badstubner I., Grossner U., Parise M., Antonini G.,

    IEEE Transactions on Magnetics

    Abstract

    The partial element equivalent circuit method is a well-known numerical technique that is used to solve Maxwell’s equations in their integral equation form. The application of the PEEC method to modeling domains with non-orthogonal three-dimensional geometries requires the computation of the interaction integrals to be performed numerically, thus slowing down the overall computation. This work presents a new technique that allows improving the computation of the interaction integrals of the PEEC method for non-orthogonal geometries under the quasi-static hypothesis. To this purpose, a voxelization approach that automatically decomposes non-orthogonal volumes in elementary parallelepipeds is used, allowing the implementation of closed-form formulas for the interaction integrals and completely avoiding numerical integration. The proposed approach is applied to three example problems exhibiting very good accuracy and excellent speed-up compared to the standard one using the numerical integration.

    Keywords: Equivalent circuits , Geometry , Integral equations , Integral equations , Magnetic circuits , Magnetic domains , magnetic fields , magnetic material modeling , Mathematical models , partial element equivalent circuit (PEEC) method , Standards , voxel

  5. Articolo su rivista2022

    Engineering knowledge formalization and proposition for informatics development towards a CAD-integrated DfX system for product design

    Favi C., Campi F., Germani M., Mandolini M.,

    Advanced Engineering Informatics, 51

    Product design and engineering

    Abstract

    Target design methodologies (DfX) were developed to cope with specific engineering design issues such as cost-effectiveness, manufacturability, assemblability, maintainability, among others. However, DfX methodologies are undergoing the lack of real integration with 3D CAD systems. Their principles are currently applied downstream of the 3D modelling by following the well-known rules available from the literature and engineers' know-how (tacit internal knowledge). This paper provides a method to formalize complex DfX engineering knowledge into explicit knowledge that can be reused for Advanced Engineering Informatics to aid designers and engineers in developing mechanical products. This research work wants to define a general method (ontology) able to couple DfX design guidelines (engineering knowledge) with geometrical product features of a product 3D model (engineering parametric data). A common layer for all DfX methods (horizontal) and dedicated layers for each DfX method (vertical) allow creating the suitable ontology for the systematic collection of the DfX rules considering each target. Moreover, the proposed framework is the first step for developing (future work) a software tool to assist engineers and designers during product development (3D CAD modelling). A design for assembly (DfA) case study shows how to collect assembly rules in the given framework. It demonstrates the applicability of the CAD-integrated DfX system in the mechanical design of a jig-crane. Several benefits are recognized: (i) systematic collection of DfA rules for informatics development, (ii) identification of assembly issues in the product development process, and (iii) reduction of effort and time during the design review.

    Keywords: CAD , Design guidelines , Design rules , DfX , Engineering knowledge , Feature recognition , Ontology

  6. Articolo su rivista2022

    CAD-integrated design for manufacturing and assembly in mechanical design

    Campi F., Favi C., Germani M., Mandolini M.,

    International Journal of Computer Integrated Manufacturing, 35(3), pp. 282-325

    Product design and engineering

    Abstract

    Design for Manufacturing and Assembly (DfMA) is a consolidated engineering activity that suffers a real integration with 3D CAD systems. DfMA principles are currently applied downstream of the 3D modelling, by following the well-known rules available from the literature and company's know-how. The paper provides a method to acquire, elaborate and represent DfMA rules sets to aid designers and engineers in developing mechanical products. This research work wants to define a general method able to couple DfMA design guidelines (knowledge-based design) with geometrical product features available by the investigation of the 3D model. The analysis of the 3D CAD model allows to anticipate manufacturing issues and to control manufacturing cost during product design. Moreover, a framework to embed this approach within a 3D CAD system is presented for future development in a software tool. Two case studies, a simple casing made of six parts and a centrifugal pump made of sixty-eight parts, highlight how the proposed method allows easy deployment of this approach in DfMA projects. Several benefits are recognized: (i) anticipation of manufacturing and assembly issues, (ii) reduction of manufacturing and assembly cost and, (iii) reduction of effort and time required by designers during the product development process.

    Keywords: cad , design guidelines , dfa , DfM , feature recognition

  7. Articolo su rivista2022

    Towards the Development of a Device for Assessing the Pliability of Burn Scars

    Dalle Mura F., Governi L., Furferi R., Cervo M., Puggelli L.,

    Frontiers in Bioengineering and Biotechnology, 10

    3D scanningMethods for medical applications

    Abstract

    Burn injuries requires post-accident medical treatment. However, the treatment of burns does not end with first aid because scarred skin must be managed for many years, and in some circumstances, for life. The methods used to evaluate the state of a burn scar based, for instance, on Patient and Observer Scar Assessment Scale or similar ones, often lacks in univocally assessing the scarred skin's state of health. As a result, the primary aim of this research is to design and build a prototype that can support the doctor during scar assessment, and eventually therapy, by providing objective information on the state of the lesion, particularly the value of skin pliability. The developed tool is based on the depressomassage treatment probe named LPG, currently used to treat burn scars in a number of hospitals. It consists of a non-invasive massage technique using a mechanical device to suction and mobilize scar tissue and is used as a post-operative treatment to speed up the healing process to make the mark of the scar less visible. The prototype is specifically designed to be manufactured using Additive Manufacturing and was validated comparing its performances against the ones of a certified instrument (i.e., the Romer Absolute ARM with RS1 probe). Validation was carried out by designing and developing a tool to put the RS1 probe in the same measurement conditions of the new prototype probe. Tests performed to assess the performance of the devised prototype show that the probe developed in this work is able to provide measurements with a sufficient degree of accuracy (maximum error ±0.1 mm) to be adopted for a reliable estimation of the pliability value in a hospital environment.

    Keywords: 3D measurement , additive manufacturing (3D printing) , burn scars , pliability , reverse engineering

  8. Articolo su rivista2022

    Systematic integration of 2D and 3D sources for the virtual reconstruction of lost heritage artefacts: the equestrian monument of Francesco III d'Este (1774–1796, Modena, Italy)

    Gherardini F., Sirocchi S.,

    Heritage Science, 10(1)

    Abstract

    The role of 3D virtual reconstruction of lost heritage artefacts is acquiring ever-greater importance, as a support for archaeological research and art history studies, as well as a vehicle for the cultural and evocative involvement of the end-user. The main risk of virtual reconstruction is the lack of a faithful restitution but, conversely, very often the artefact conservation state does not allow a complete 3D reconstruction. Therefore, 2D sources, both textual and iconographic, represent a precious integration and completion of the existing 3D sources. This paper proposes an operating systematic workflow to integrate retrieved 2D and 3D sources and assess their compatibility for the virtual reconstruction of lost heritage artefacts using and integrating 3D survey and digital modelling. As a case study, we virtually reconstructed the lost equestrian monument of Duke Francesco III d'Este, 7 m high, built in 1774 in Modena, Italy, by the sculptor Giovanni Antonio Cybei and completely destroyed a little over 20 years later during the revolutionary uprisings. Following the proposed workflow, we integrate data coming from: a still preserved preparatory stucco model, paintings and engravings showing the missing details of the 3D model, a series of urban views returning the proportion and positioning of the monument (statue, pedestal and base), a fragment of the right foot providing the statue size and the appearance of the original white Carrara marble. The final 3D digital model shows a faithful correspondence to the 2D sources and guarantees an effective user's fruition thanks to dedicated virtual applications. Besides the scientific and cultural goal, we highlight the evocative role of this work, which has contributed to the restitution of a monument that is unknown to most citizens and visitors.

    Keywords: 3D modelling , Close-range photogrammetry , Equestrian statue , Iconography , Virtual reconstruction

  9. Contributo a convegno2022

    An Analytical Model for Robot-Based Grinding of Axisymmetric Mold Inserts Using a Rotary Unit

    Tamassia E., Hähnel S., Pini F., Grunwald T., Bergs T., Leali F.,

    Lecture Notes in Mechanical Engineering, pp. 605-614

    Product design and engineering

    Abstract

    The grinding of mold inserts used for injection molding aims to improve the surface roughness according to precise quality standards. The insert surface must also have a surface topography that facilitates the release of the plastic material at the end of the injection process. In particular, fine machining lines must be parallel to the extraction direction from the mold to avoid the sticking of plastic material and subsequent surface damages compromising the functionality of the finished product. However, this step in the production chain is most often conducted manually. This paper presents an analytical model to grind a truncated cone-shaped mold insert for the mass production of plastic cups. The automated solution consists of a flexible robotic system equipped with a rotating external axis to improve the accessibility of the tool to the surface to be machined. The tool path programming requires the development of an analytical model considering the simultaneous motion of the insert and the robot joints. The effectiveness of the developed model is evaluated in terms of final surface quality, grinding lines direction, and total process time. The automated strategy developed can be easily implemented with machine tools and applied to inserts with different axisymmetric geometries.

    Keywords: Automated fine machining , CAM programming , Grinding lines , Mold insert , Robot manufacturing

  10. Articolo su rivista2022

    Statistical shape modelling of the human mandible: 3D shape predictions based on external morphometric features

    Pascoletti G.,

    International Journal on Interactive Design and Manufacturing

    Methods for medical applicationsVirtual prototyping and digital twin

    Abstract

    One of the main limitations in subject-centred design approach is represented by getting 3D models of the region of interest. Indeed, 3D reconstruction from imaging data (i.e., computed tomography scans) is expensive and exposes the subject to high radiation doses. Statistical Shape Models (SSMs) are mathematical models able to describe the variability associated to a population and allow predicting new shapes tuning model parameters. These parameters almost never have a physical meaning and so they cannot be directly related to morphometric features. In this study a gender-combined SSM model of the human mandible was setup, using Generalised Procrustes Analysis and Principal Component Analysis on a dataset of fifty mandibles. Twelve morphometric features, able to characterise the mandibular bone and readily collectable during external examinations, were recorded and correlated to SSM parameters by a multiple linear regression approach. Then a cross-validation procedure was performed on a control set to determine the combination of features able to minimise the average deviation between real and predicted shapes. Compactness of the SSM and main modes of deformations have been investigated and results consistent with previous works involving a higher number of shapes were found. A combination of five features was proved to characterise predicted shapes minimising the average error. As completion of the work, a male SSM was developed and performances compared with those of the combined SSM. The features-based model here proposed could represent a useful and easy-to-use tool for the generation of 3D customised models within a virtual interactive design environment.

    Keywords: Features selection , Mandible , Morphometric measurements , PCA , Predicted shapes , Statistical shape model , Subject-specific model

  11. Articolo su rivista2022

    A Framework for Hybrid Manufacturing in Robotic Cells

    Lettori J., Raffaeli R., Peruzzini M., Pellicciari M.,

    Computer-Aided Design and Applications, 19(5), pp. 1029-1041

    Additive manufacturingVirtual prototyping and digital twin

    Abstract

    Compared to other additive technologies, Wire and Arc Additive Manufacturing (WAAM) offers high deposition rates, flexibility and a larger build volume as well as reduction of material waste. WAAM can be combined with a subtractive technology in hybrid robotic cells to further increase the application scope, thus producing products with improved surface finish where needed. However, there are some open issues that limit this process. So, the main goal of this paper is to review current research developments and provide a framework aimed at manufacturing parts by hybrid cells. A procedure is defined which moves from the evaluation of the designed shapes, their analysis to identify a proper manufacturing sequence until the elaboration of the instructions for the cell automaton controllers. Main WAAM issues are outlined to identify main research directions, and a test case is presented to highlight the process phases.

    Keywords: Hybrid manufacturing , Process planning , Robotic cell , Wire and arc additive manufacturing

  12. Articolo su rivista2022

    Enhancing Product Semantics Understanding Through Automatic Part Type Recognition in CAD Assembly Models

    Bonino B., Giannini F., Monti M., Raffaeli R.,

    Computer-Aided Design and Applications, 19(5), pp. 896-912

    Product design and engineering

    Abstract

    Focus of this work is the recognition of the standard parts contained in a CAD assembly model, with the aim of enhancing the model semantics. Standard parts are components typically used in mechanical industry, which have a specificc engineering meaning and follow international standards. In particular eight categories of standard parts are considered, i.e. screws, nuts, O-ring, washers, circlips,keys, studs and pins. The provided algorithm relies on the geometric and topological analysis of the CAD model parts. A part is assigned to one of the categories if it satisfies the geometric requirements extracted for that specific category, based on engineering knowledge and design rules. In addition, if a part is recognized as standard part, besides the class of membership, further information is provided as result, namely its engineering dimensions.

    Keywords: Assembly Semantics , CAD Model Processing , Part Classification , Standard Part Detection , Type Recognition

  13. Articolo su rivista2022

    Systematic Design of Ancient Machines' Models: Leonardo da Vinci's Glider

    Fiorineschi L., Rotini F., Barsanti R.,

    Heritage, 5(3), pp. 1593-1611

    Product design and engineering

    Abstract

    Virtual or physical models of ancient machines are often used for museum exhibitions, documentaries and/or cinematographic works. Especially for high-fidelity models, complex activities are required, which actually lead the different stakeholders involved in the process to “design” an artifact (the model). As with any design process, the design of models of ancient machines can also benefit from the support of structured methods that guide the designers from the early “ideas” to the final design. This paper proposes a systematic approach specifically tailored for the interpretation and design of ancient machines, where a methodological tool is provided to manage both idea-generation and information-gathering activities. The method was applied to the design of a model of the delta wing conceived by Leonardo da Vinci (i.e., the glider represented in the Codex Madrid 1, Folio 64r), allowing to analyze and obtain an embodiment of the machine with the required fidelity level, thought to be realized in real scale.

    Keywords: ancient machines , CAD , delta wing , design methods , design process , glider , Leonardo da Vinci , museum models , systematic design , technological heritage

  14. Articolo su rivista2022

    Vision Transformer for femur fracture classification

    Tanzi L., Audisio A., Cirrincione G., Aprato A., Vezzetti E.,

    Injury, 53(7), pp. 2625-2634

    Abstract

    Introduction: In recent years, the scientific community focused on developing Computer-Aided Diagnosis (CAD) tools that could improve clinicians' bone fractures diagnosis, primarily based on Convolutional Neural Networks (CNNs). However, the discerning accuracy of fractures' subtypes was far from optimal. The aim of the study was 1) to evaluate a new CAD system based on Vision Transformers (ViT), a very recent and powerful deep learning technique, and 2) to assess whether clinicians' diagnostic accuracy could be improved using this system. Materials and methods: 4207 manually annotated images were used and distributed, by following the AO/OTA classification, in different fracture types. The ViT architecture was used and compared with a classic CNN and a multistage architecture composed of successive CNNs. To demonstrate the reliability of this approach, (1) the attention maps were used to visualize the most relevant areas of the images, (2) the performance of a generic CNN and ViT was compared through unsupervised learning techniques, and (3) 11 clinicians were asked to evaluate and classify 150 proximal femur fractures' images with and without the help of the ViT, then results were compared for potential improvement. Results: The ViT was able to predict 83% of the test images correctly. Precision, recall and F1-score were 0.77 (CI 0.64–0.90), 0.76 (CI 0.62–0.91) and 0.77 (CI 0.64–0.89), respectively. The clinicians' diagnostic improvement was 29% (accuracy 97%; p 0.003) when supported by ViT's predictions, outperforming the algorithm alone. Conclusions: This paper showed the potential of Vision Transformers in bone fracture classification. For the first time, good results were obtained in sub-fractures classification, outperforming the state of the art. Accordingly, the assisted diagnosis yielded the best results, proving the effectiveness of collaborative work between neural networks and clinicians.

    Keywords: CAD system , Deep learning , Femur fracture , Self-attention , Vision transformer

  15. Articolo su rivista2022

    The impact of 3D models on positive surgical margins after robot-assisted radical prostatectomy

    Checcucci E., Pecoraro A., Amparore D., De Cillis S., Granato S., Volpi G., Sica M., Verri P., Piana A., Piazzolla P., Manfredi M., Vezzetti E., Di Dio M., Fiori C., Porpiglia F.,

    World Journal of Urology

    Methods for medical applicationsVirtual and augmented reality

    Abstract

    Purpose: To evaluate the role of 3D models on positive surgical margin rate (PSM) rate in patients who underwent robot-assisted radical prostatectomy (RARP) compared to a no-3D control group. Secondarily, we evaluated the postoperative functional and oncological outcomes. Methods: Prospective study enrolling patients with localized prostate cancer (PCa) undergoing RARP with mp-MRI-based 3D model reconstruction, displayed in a cognitive or augmented-reality fashion, at our Centre from 01/2016 to 01/2020. A control no-3D group was extracted from the last two years of our Institutional RARP database. PSMr between the two groups was evaluated and multivariable linear regression (MLR) models were applied. Finally, Kaplan–Meier estimator was used to calculate biochemical recurrence at 12 months after the intervention. Results: 160 patients were enrolled in the 3D Group, while 640 were selected for the Control Group. A more conservative NS approach was registered in the 3D Group (full NS 20.6% vs 12.7%; intermediate NS 38.1% vs 38.0%; standard NS 41.2% vs 49.2%; p = 0.02). 3D Group patients had lower PSM rates (25 vs. 35.1%, p = 0.01). At MLR models, the availability of 3D technology (p = 0.005) and the absence of extracapsular extension (ECE, p = 0.004) at mp-MRI were independent predictors of lower PSMr. Moreover, 3D model represented a significant protective factor for PSM in patients with ECE or pT3 disease. Conclusion: The availability of 3D models during the intervention allows to modulate the NS approach, limiting the occurrence of PSM, especially in patients with ECE at mp-MRI or pT3 PCa.

    Keywords: 3D modeling , Augmented reality , Prostate cancer , Robotic surgery , Surgical margins

  16. Contributo a convegno2022

    K-means Clustering and Hadamard Metric for Graphs Modelling

    Cattani P., Villecco F.,

    Lecture Notes in Networks and Systems, 472 LNNS, pp. 443-448

    Abstract

    Modelling a geometric surface or contour surface is a modern field involving a wide range of topics such as mathematics, computer science, engineering design. The main task in modelling a geometric surface is to approximation the shape of the contour surface of a 3D solid object the most efficient way. In this paper we will give a method to optimize the geometric model, by defining a local sampling of the mesh, based on k-means method and minimization of the Hausdorff measure with an homologous model.

    Keywords: Clustering , Geometric modelling , Hausdorff distance , k-means

  17. Contributo a convegno2022

    User-Centered Back-Support Exoskeleton: Design and Prototyping

    Roveda L., Pesenti M., Rossi M., Rodriguez M.C., Pedrocchi A., Braghin F., Gandolla M.,

    Procedia CIRP, 107, pp. 522-527

    Abstract

    Exhausting manual labor is still predominant in the industrial context. It typically consists in manipulating heavy parts or working in non-ergonomic conditions. The resulting work-related musculoskeletal disorders are a major problem to tackle. The most-affected body section is the the lumbar spine. Recently, exoskeletons have been identified as a possible non-invasive solution to reduce the impact of low-back pain. State-of-the-art prototypes have been optimized to: follow unconstrained human kinematics, (partially) relieve the load on assisted joints, and allow anthropometric adaptation. Yet, this technology still has limited adoption. Manufacturing optimization may address the following limitations: bulky/heavy resulting designs, complex assembly and maintenance, high manufacturing costs, long procedures for adaptation and wearing, and psychological effects (e.g., cognitive load and usability). In this contribution, the aforementioned issues are tackled improving a previous low-back exoskeleton prototype. In particular, kinematic analysis, Finite-Element-Method, and topological optimization have been combined to obtain a lightweight prototype, testing different materials (Nylon, carbon-fiber reinforced PC/ABS, etc.). We applied both Design for Assembly and Design for Manufacturability. The resulting exoskeleton prototype is described in the paper, ready for end-user field tests.

    Keywords: back-support; exoskeleton , backbone-based kinematics , industry4.0 , industry5.0 , materials selection , mechanical design , topological optimization

  18. Contributo a convegno2022

    Correlation Between IBSI Morphological Features and Manually-Annotated Shape Attributes on Lung Lesions at CT

    Bianconi F., Fravolini M.L., Pascoletti G., Palumbo I., Scialpi M., Aristei C., Palumbo B.,

    Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 13413 LNCS, pp. 767-777

    Image Processing & ApplicationsMethods for medical applications

    Abstract

    Radiological examination of pulmonary nodules on CT involves the assessment of the nodules' size and morphology, a procedure usually performed manually. In recent years computer-assisted analysis of indeterminate lung nodules has been receiving increasing research attention as a potential means to improve the diagnosis, treatment and follow-up of patients with lung cancer. Computerised analysis relies on the extraction of objective, reproducible and standardised imaging features. In this context the aim of this work was to evaluate the correlation between nine IBSI-compliant morphological features and three manually-assigned radiological attributes – lobulation, sphericity and spiculation. Experimenting on 300 lung nodules from the open-access LIDC-IDRI dataset we found that the correlation between the computer-calculated features and the manually-assigned visual scores was at best moderate (Pearson's r between -0.61 and 0.59; Spearman's ρ between -0.59 and 0.56). We conclude that the morphological features investigated here have moderate ability to match/explain manually-annotated lobulation, sphericity and spiculation.

    Keywords: Lung cancer , Morphological features , Pulmonary nodules , Radiomics

  19. Contributo a convegno2022

    A new generation of highly customized Mg alloy-based implants

    Serratore G., Piccininni A., de Napoli L., Conte R., Sahin E., Kaya A.A., Cotrut C.M., Vladescu A., Beck-Sickinger A.G., Guglielmi P., Cusanno A., Palumbo G., Tatullo M., Ambrogio G.,

    Procedia CIRP, 110(C), pp. 249-254

    3D scanningGeometric dimensioning, tolerancing and inspectionMethods for medical applications

    Abstract

    In the last years, the precision and personalized medicine is pushing the biomedical research efforts towards the direction of implant surgery requiring only 1-step approach: this goal has been achieved after the introduction of resorbable implants. The resorbable prosthetic support is indicated for temporary prosthetic applications, such as bone fractures fixation, or all those conditions usually treated with metal implants then removed with a second surgery, just after the healing of the bone defect. Biodegradable, bioactive and customizable implants for the treatment of bone fractures, both efficient in bearing the functional loads, and showing good biocompatibility and degradation properties matching the bone tissue healing, are still lacking. These premises have led to consider Magnesium (Mg) and its alloys as very promising candidates for the development of temporary, resorbable implants. However, the very high corrosion rate of Mg is the main problem, not yet solved. The material needs to be properly treated/coated, as well as manufactured, in order to design the most suitable duration of the temporary prosthesis permanence in situ. An innovative and interdisciplinary approach has been developed within the M.Era-Net ISIDE project and it is here briefly detailed with a special focus on the highlighted application fields.

    Keywords: customade prostesis , Mg alloys , Reabsorbable implants

  20. Articolo su rivista2022

    In Silico Meta-Analysis of Boundary Conditions for Experimental Tests on the Lumbar Spine

    Borrelli S., Putame G., Pascoletti G., Terzini M., Zanetti E. M.,

    Annals of Biomedical Engineering, 50(10), pp. 1243-1254

    Methods for medical applicationsProduct design and engineering

    Abstract

    The study of the spine range of motion under given external load has been the object of many studies in literature, finalised to a better understanding of the spine biomechanics, its physiology, eventual pathologic conditions and possible rehabilitation strategies. However, the huge amount of experimental work performed so far cannot be straightforwardly analysed due to significant differences among loading set-ups. This work performs a meta-analysis of various boundary conditions in literature, focusing on the flexion/extension behaviour of the lumbar spine. The comparison among range of motions is performed virtually through a validated multibody model. Results clearly illustrated the effect of various boundary conditions which can be met in literature, so justifying differences of biomechanical behaviours reported by authors implementing different set-up: for example, a higher value of the follower load can indeed result in a stiffer behaviour; the application of force producing spurious moments results in an apparently more deformable behaviour, however the respective effects change at various segments along the spine due to its natural curvature. These outcomes are reported not only in qualitative, but also in quantitative terms. The numerical approach here followed to perform the meta-analysis is original and it proved to be effective thanks to the bypass of the natural variability among specimens which might completely or partially hinder the effect of some boundary conditions. In addition, it can provide very complete information since the behaviour of each functional spinal unit can be recorded. On the whole, the work provided an extensive review of lumbar spine loading in flexion/extension.

    Keywords: Biomechanics , Follower load , Lumbar spine , Mechanical tests , Multibody , ROM